This volume examines how American Studies has transformed in response to global, political, and intellectual shifts. It gathers leading scholars who question the discipline’s traditional narratives and national frameworks. Essays explore intersections of race, gender, sexuality, and transnationalism to critique and expand the field. The contributors advocate for an interdisciplinary, politically engaged approach to American cultural analysis. The book critically reflects on the institutional and ideological boundaries of the field. It ultimately envisions multiple, contested futures for American Studies beyond U.S.-centric paradigms.